Genes and Addiction: Our Genetics Are Responsible for Our Addictions

Tobacco and alcohol use, both genetically inheritable behaviors, influence risk for several complex diseases and disorders and are leading causes of mortality.
Genes and Addiction

Scientists have concluded that the risk of addiction is a complex combination of both genes and environmental influences.

Despite advances in the science of genetics, it has been extremely difficult to spot the possible genetic contributions to addiction as a result of it likely involves a combination of inherited variants in multiple genes. To find answers related to nicotine addiction, for example, scientists must study complex and nuanced queries like, do certain genetic variants play a role in initiation of smoking and others play a role in behaviors leading to heavy smoking?

The University of Minnesota was part of a research collaboration that conducted the primary study, recently published in Nature genetics, to spot hundreds of genomic locations related to addictive behaviors.

Researchers found over five hundred genetic variants that affect the use of and addiction to tobacco and alcohol. Until now, only a few of such variants hadbeen identified.

Is Addiction a Disease?

Consider heart disease. It's partly due to genes and partly due to poor life style choices such as bad diet, lack of exercise, and smoking. the same is true for alternative common diseases like adult-onset diabetes.

Many types of cancers are due to a combination of genes and life style. but if your doctor said that you had diabetes or heart disease, you would not think you were bad person. you'd think, "What am i able to do to overcome this disease?" that's how you should approach addiction. Addiction is like most major diseases.

Addiction isn't a weakness. the fact that addiction crosses all socio-economic boundaries confirms that addiction is a disease. People who do not know about addiction can tell you that just need to be stronger to control your use. but if that was true then only unsuccessful people or unmotivated people would have an addiction, and yet 100 PC of high-functioning executives have an addiction.

If you're thinking that of addiction as a weakness, you may paint yourself into a corner that you just cannot get out of. You may specialize in being stronger and making an attempt to regulate your use, rather than treating addiction sort of a illness and specializing in stopping your use.

The study showed:

·       566 genetic variants in 406 genomic locations associated with multiple stages of tobacco use (initiation, cessation, and heaviness) and alcohol use;

·     150 loci, or locations in the genome, showing proof for association with two or more of the characteristics listed above;

·      Increased genetic risk for smoking was associated with multiplied risk for a wide variety of health conditions like obesity and coronary artery disease;

·       Genetic risk for alcohol use was associated with lower disease risk.

One goal of genetic research is to assist develop improved treatments. each new addiction gene identified becomes a potential "drug target." That is, researchers can focus on one gene product and develop a drug that modifies its activity. In thus doing, signals or pathways in the brain may be modified or stabilized to restore proper brain function.

Body Parts: Falling in Love Changes A Woman’s Body Chemistry

We’ve all behaved like love struck teenagers at some purpose in our lives and it turns out, first date butterflies and therefore the inevitable over-analysis of your text exchange is simply a part of human nature.

Have you ever looked at your partner lovingly and felt your heart flutter, palms sweat, or mood instantly get better?


·         Love leads to biological changes that have been observed in scientific research.

·         Being in love can reduce stress, relieve pain, and make you happier.

·         Here are seven ways your body and brain change when you fall in love.

What is love Best relationship Love quotes body parts.

During our first childhood “crush,” we tend to all experienced butterflies in the stomach, nervousness, and a racing heartbeat. We were infatuated and couldn’t take our eyes off of the object of our affection.

According to a new study conducted by researchers at the University of California, falling in love with someone sparks genetic changes in women’s bodies.

The investigation – which is the first of its kind to uncover the impact of love on our genes – concerned taking blood samples from 47 young women, as they embarked upon new relationships over the course of 2 years.

Researchers analyzed genetic changes in those who fell in love and discovered that when Cupid’s arrow struck, women weren't only affected psychologically but physically too, through palpitations and obsessive thinking.

WHAT HAPPENS TO YOUR BODY WHEN YOU FALL IN LOVE

Your chemical romance

Ah, love. in the heady days of a mutual crush, pulses race, knees go weak, and heads reel. therefore strong are these feelings, they’ve launched a thousand songs and poems.

But it’s more than just a metaphor. Love does indeed impact our bodies in measurable ways.

You feel totally different and are different. Read on to find out what researchers have discovered regarding this thing called love.

YOU FEEL “ADDICTED”

Falling in love, and its effects on the body, are strikingly similar to being addicted to drugs. Chemicals that cause a euphoric high – adrenaline, dopamine, oxytocin, and vasopressin, are all released at some point during intimacy. Dopamine is the brain’s pleasure chemical, and is what causes feelings of elation and energy around our loved one.

Upon this discovery, the scientists also investigated how the levels of interferon amendment throughout the course of a woman’s relationship and discovered that those who eventually fell out of love saw a reduction in the protein.

“Falling in love is one of the most psychologically potent experiences in human life,” the analysis team concluded. “New romantic love is accompanied not only by psychological changes.”

Testosterone takes off

Although testosterone is thought of as a macho hormone, it helps stoke the fire in both sexes.

“It is simply one of the many pieces for romantic love,” says Fisher. “Sex can come on your testosterone levels.”

Men naturally have higher testosterone levels and trace amounts in saliva. One theory says that once people lock lips, the transfer of this hormone could increase sexual desire in a partner.

Being bitten by the “love bug” isn’t just a poetic expression anymore.

Scientists have found that falling head over heels for someone causes girls specifically to produce a specific kind of protein.

“New romantic love is accompanied not only by psychological changes, however physiological changes as well,” UCLA researchers wrote, according to The Sunday Times.

The scientists took blood samples from 47 young, newly enamored women and found that their bodies were producinginterferon, a protein typically deployed to fight viruses.

When the flame starts to die out, the body’s interferon levels taper off, researchers found.

Men weren’t included in the study, but the authors indicated they need to like to study them next.

Now, the research team is intrigued to find out how men are influenced by love and plan to uncover how a male’s genetic response to romance differs to women.

High Fiber Foods You Should Eat: It's Not Just for Adults

High Fiber Foods And AdultsTo get the fiber your body wants, eat a well-balanced diet that includes delicious high-fiber foods.You know how important fiber is for overall health, making meals a lot of filling and staying "regular." 
But did you know that children need their fair share of fiber, too? And for the same reasons.
High Fiber Foods
Grams of Fiber by Age: High Fiber Foods, weight lose, health care, hair
  • Ages 1-3: 19 g.
  • Ages 4-8: 25 g.
  • Ages 9-13: 26 g for girls, 31 g for boys.
  • Ages 14-18: 26 g for girls, 38 g for boys.
How much is enough? Normally, the U.S. Institute of medicine states that observance fiber intake ought to start early in life, and by their teen years, kids need nearly as much fiber as adults. High Fiber Foods, weight lose, health care, hair care, Beauty tips, Adults.

Why Fiber?

Fiber are a few things the body needs but never actually digests—in fact, it remains more or less an equivalent from plate to toilet. It comes in two varieties, soluble and insoluble, and most plant-based foods contain a mixture of the two.
Soluble fiber turns to gel in the stomach and slows digestion, which helps lower cholesterol and blood glucose. Insoluble fiber, on the other hand, remains unchanged all the way to the colon, making waste heavier and softer so it can shimmy through the intestines additional simply. Regardless of these differences, neither type of fiber is ever absorbed into the body.

Fiber is incredibly important.

It leaves your stomach undigested and finishes up in your colon, where it feeds friendly gut bacteria, leading to various health benefits.
Certain varieties of fiber may also promote weight loss, lower blood sugar levels and fight constipation.
The recommended daily intake is 25 grams for women and 38 grams for men.
However, most people are only eating around half of that, or 15–17 grams of fiber per day.
Fortunately, increasing your fiber intake is comparatively simple — simply integrate foods into your diet that have a high percentage (%) of fiber per weight.
Skipping out on a daily dose of fiber typically leads to constipation, which can make going to the bathroom painful and uncomfortable—hence the term “backed up.” eating too little fiber will make it tough to control blood sugar and craving as a result of fiber regulates the speed of digestion and contributes to satiety (aka feeling full).
There can be too much of a decent thing, though. Overdoing it with fiber can move food through the intestines too quickly, which means fewer minerals get absorbed from food. It can also end in uncoffin gas, bloating, and cramping, especially when fiber intake is dramatically increased overnight.
The American Academy of pediatrics says to remember the number 5 -- make sure kids eat at least 5 servings of fruits and vegetables each day plus other good sources of fiber, like whole grains.
The nutrition facts panel on prepackaged foods can assist you make fiber-rich choices. If a food claims to be a good source of fiber, the fiber grams will be listed under carbohydrates. "Excellent" sources have 5 or more grams of fiber per serving. "Good" sources have a minimum of 3 grams.
Simple changes can add up to a giant improvement.
When serving veggies and fruit, do not remove edible peels -- they contain fiber, plus there is less prepping for you. when you do cook produce, avoid overcooking, that destroys fiber. Dried fruits, pumpkin and sunflower seeds, and freshly made popcorn all make nice high-fiber snacks.
Keep in mind that the sooner in their lives that you just start kids on a fiber-rich diet, the easier it'll be for them to carry this healthy habit into adulthood.
High Fiber Foods You Should Eat: It's Not Just for Adults. Health care, weight lose.
The U.S. Food and Drug Administration has a video with tips on getting kids to eat more fiber.

Sony Accepts - It Was Accidentally Blocking Kodi Android TV App, Fix Coming

Sony Says it will Fix Kodi problem In Its Next software Update.Sony has confirmed it's working on a fix to what's currently a known Kodi issue for users of its android TV platform. The fix is expected to become available soon and will be distributed by inclusion in an upcoming OTA update sent directly to devices.
Sony Kodi Android TV App

Around half week ago we reported that Sony appeared to be blocking the installation of Kodi — the occasionally maligned media-streaming platform — on some of its recent android TVs. whereas there's an effective block in place, we're told by Sony that it was an accident, and the next software update for affected platforms will deliver a fix.
Kodi is one of the most well-liked home-streaming services that's legal to buy and watch free content. However, once users started installing special third-party add-ons to stream copyrighted movies and tv shows, it earned itself a bad piracy-associated reputation.
Despite the bad name, Kodi still remains popular with the public. looking at its increased popularity, even Sony electronics actively promoted Kodi on its website and recommended users of its android TVs to download Kodi to access add-ons.
Sony reached out to United States with the following comment:
Thank you for bringing this to our attention. when looking into the issue further, we’ve discovered a software system issue on our end that's incorrectly classifying Kodi as a kernel object (“ko”). we are acting on a fix for this issue to include in our next software update.
This actually showing neatness ties in with claims that had previously been made by Sony android TV device owners. Through the Kodi forums, where the issues first raised its head, users noted they were able to get the app to work by changing the corresponding package ID. Therefore Sony’s claims there was an identification issue marry well with those user reports.
If you are a developer (or a more extreme android enthusiast), you'll be able to probably see how the error cropped up. for everyone else, the simple version is that Sony's software was looking at the package name, incorrectly seeing it as a linux kernel object (due to its *.ko package name), and refusing to install. This also explains why folks in the Kodi forum were able to work around the restriction by changing the ID at build time.
Irrespective of the reasoning, an update is now confirmed as in the works so anyone experiencing the problem, and who haven't opted to make use of one of the name-changed versions of the app circling on the Kodi forums, ought to expect the app to work as intended once the update has arrived.
The even simpler version is that this was just an causeless bug that Sony plans on fixing — though the mechanism behind this bug does not instill a whole heap of confidence in Sony's software prowessˢᵃᵐˢᵘⁿᵍ ᵏᵒᵈᶦ ᵏᵒᵈᶦ ᵇᵒˣ ʰᵒʷ ᵗᵒ ᶦⁿˢᵗᵃˡˡ ᵏᵒᵈᶦ ˡᵃᵗᵉˢᵗ ᵛᵉʳˢᶦᵒⁿ ᵒᶠ ᵏᵒᵈᶦ ᵏᵒᵈᶦ ᵗᵛ ˢᵘⁿⁿʸ ˡᵉᵒⁿ
If you are among those affected, you may have to wait for a fix, however it ought to be coming. Although Sony confirmed the update as coming back, it has not specified when it'll begin rolling out.

AI: Artificial Intelligence Helps Detect Early Heart Disease - Mayo Researchers

Artificial Intelligence, utilized in conjunction with EKGs, could be the key to detecting early heart problems, a new study from mayo Clinic found.
Artificial Intelligence

An AI system can effectively detect an early, pre-symptomatic stage of heart disease using simple electrocardiogram data. Applying artificial intelligence (AI) to a widely available, inexpensive test — the Electrocardiogram (EKG) — results in a straightforward, affordable early indicator of a precursor to heart failure, scientists say.


An innovative new way to analyze electrocardiogram (ECG) results using artificial intelligence might facilitate doctors quickly and cheaply identify patients most at risk of heart failure.


A new study from researchers at the mayo Clinic demonstrates a newly developed AI system that's able to detect the presence of left ventricular dysfunction, a condition currently only detectable using different more expensive and time-consuming imaging tests.

There is no inexpensive, noninvasive, painless screening tool for asymptomatic left ventricular dysfunction out there for diagnostic use, researchers said.

The study found that the best existing screening test for asymptomatic left ventricular dysfunction is to measure naturalistic peptide levels (BNP), however results of BNP have been disappointing. The take a look at conjointly needs blood draws.


The system was trained on information from over 600,000 patients, pairing electrocardiogram and echo cardiogram results. The resulting algorithmic program was subsequently tested on an independent data-set comprised of over 50,000 patients. The results were exceptionally positive, with sensitivity, specificity, and accuracy all sitting around 85 p.c. These detection rates were noted as comparable to several alternative popular screening tests, together with breast cancer mammography and prostate cancer antigens.


The study also revealed that in patients without ventricular dysfunction, those with a positive AI screen were at four times the risk of developing future ventricular dysfunction, compared with those with a negative screen. “In other words, the test not only Identified.

asymptomatic diseasehowever also predicted risk of  future diseasepresumablyby  distinctive very early, subtle ekg changes that occur before heart muscle weakness,” said Dr. Friedman.

ˢᶜᶦ ʰᵘᵇʳʰᵉᵘᵐᵃᵗᶦᶜ ᶠᵉᵛᵉʳᶜʰᶠʰᵉᵃʳᵗ ᶠᵃᶦˡᵘʳᵉᵗʳᵃⁿˢᵃᵐᶦⁿᶦᵗᶦˢ ᶦᶜᵈ ¹⁰ᶜᵃʳᵈᶦᵃᶜ ᶜᵃᵗʰᵉᵗᵉʳᶦᶻᵃᵗᶦᵒⁿᵛᵃˡᵛᵘˡᵃʳ ʰᵉᵃʳᵗ ᵈᶦˢᵉᵃˢᵉʰᵉᵃʳᵗ ᵖʳᵒᵇˡᵉᵐ ˢʸᵐᵖᵗᵒᵐˢ

Obsessive-Compulsive Symptoms in Youth: red flag for psychological issues

psychological issues(mental health): Engaging in repetitive and ritualistic behaviors is a component of typical child development. Fifty percent of mental illness begins by age 14, and three-quarters begins by age 24.
Mental Health

How do you know if someone is struggling with mental health?
There are several factors that contribute to the development of depression, anxiety, bipolar disorder and other disorders in teens and adolescents. It’s important to know what signs and symptoms to look for. Below are many signs that may indicate your adolescent or teen is struggling and needs help.
Ø Angry outbursts or inappropriate anger
Ø Panic attacks
Ø Excessive anxiety or worry
Ø difficulty concentrating
Ø difficulty making transitions
Ø extremely happy or high energy at times
Ø Talking very fast
Ø Being easily overwhelmed
Ø Depressed mood – changes in weight or appetite
Ø Feelings of worthlessness, emptiness, or guilt
Ø Intense emotions
Ø Mood swings
Ø Feels simply criticized or rejected
Ø Impaired school performance
Ø Distorted sense of self
Ø Missing school due to symptoms
However, behaviors that develop into obsessive and compulsive symptoms (OCS) may represent a red flag for serious psychiatric conditions. Researchers at the lifespan Brain Institute (LiBI) of Children’s Hospital of Philadelphia (CHOP) and the Perelman school of medicine at the University of Pennsylvania found children and young adults with OCS who conjointly admitted to having bad thoughts were more probably to also experience psychopathology, including depression and suicide. This is the first and largest study examining OCS in additional than 7,000 participants aged 11 to 21.
The findings were published online last month in the Journal of American Academy of child and Adolescent psychiatry.
While engaging in repetitive and ritualistic behavior could be a part of childhood development, a new study now says that behaviors that develop into obsessive and compulsive symptoms (OCS) might represent a red flag for serious psychiatric conditions.
Researchers divided OCS into four categories: bad thoughts, repeating/checking, symmetry, and cleaning/contamination. Over 20 % of youth admitted to having bad intrusive thoughts, including thoughts about harming oneself or others, picturing violent images or fears that one would do something bad without intending to. These children were additional seemingly to develop serious psychopathology on the far side obsessive compulsive disorder (OCD), including depression and suicide.
The study found that quite 20 per cent of youth admitted to having bad intrusive thoughts, including that about picturing violent pictures, harming one or others, or fear that one would do something bad without intending to.
Experts said these were the children who were more likely to develop serious psychopathology on the far side obsessive compulsive disorder (OCD), including depression and suicide.
OCS was common in individuals who didn't seek mental health treatments (38.2 percent). Only 3 % met the threshold for OCD. OCS was a lot of common in females and after puberty. The researchers suggest OCS could also be a window for clinicians to probe and establish serious psychiatric conditions.
Speaking about the study, the principal investigator Raquel Gur, MD, PhD, director of the LiBI and a professor of psychiatry, Neurology and Radiology in the Perelman school of medicine, said that their hope is that these results will propel mental state professionals to probe for these symptoms throughout their patients’ visits as they'll be vital for distinctive adolescents who are on a downwards spiral towards psychological issues.

Genetic Testing Guidelines "Not Helpful" in Breast Cancer

International acclaim for new breast cancer treatment, Breast Reconstruction Fat Grafting.

The acceptance of clinical results at an eminent peer-reviewed forum like SABCS may be a strong validation of Niramai’s trial results. Artificial intelligence-based Indian health-tech company Niramai received international acclaim at the recent San Antonio breast cancer symposium (SABCS).
Genetic Testing
It was the only Indian company to present at one in every of the biggest breast cancer conferences within the world, well-attended by oncologists and cancer researchers.
India-based health tech company Niramai has received international acclaim at the recent San Antonio breast cancer symposium (SABCS). it had been the only Indian company to present at one of the largest breast cancer conferences in the world, which is well-attended by oncologists and cancer researchers.
The acceptance of clinical results at an eminent peer-reviewed forum like SABCS could be a strong validation of Niramai’s trial results. a chance to present the work to the international experts and receiving their positive feedback puts Niramai’s indigenous technology on the map beside leading innovations across the world.
At the conference, Niramai presented results of a retrospective multisite comparative study of 247 patients across 3 reputed cancer hospitals in Bharat. These demonstrated higher sensitivity and comparable specificity of the solution to mammography.
Dr Geetha Manjunath, CEO & CTO, Niramai, spoke about how their innovative solution uses artificial intelligence (AI) for detecting early stage breast cancer with results reminiscent of commonplace modalities. Niramai’s solution is called Thermalytix, an automated diagnostic tool, which combines thermal imaging with artificial intelligence. the solution is radiation-free, accurate, machine-driven and works on all women irrespective of their breast density. “We were privileged to get an opportunity to present at SABCS 2018, a prestigious forum for interaction and learning for a broad spectrum of medical practitioners, researchers and health professionals with a interest in breast cancer,” said Dr Geetha Manjunath.
US-based radiologists were receptive towards the solution, with, as an example, Dr Sheldon Feldman, a brand new York-based expert in breast surgery and surgical oncology, saying: “I am very intrigued by this promising technology. It’s like a major advance in technology. I hope to collaborate and be helpful to further validate its efficacy”.
This year, SABCS attracted more than 7000 participants from over 80 countries, as well as medical oncologists, radiation oncologists, researchers, and other healthcare professionals.

Vitamin A - The most dangerous foods for the liver

Your body needs vitamin A, and it’s fine to get it from plants like fresh fruits and vegetables, especially those that are red, orange, and yellow. however if you're taking supplements that have high doses of vitamin A, that can be a problem for your liver. check with your doctor before you're taking any further vitamin A because you probably don’t want it.
Vitamin A

Inappropriate foods and drinks is one in all the foremost serious factors of possible liver problems. Scientists named the most dangerous products to the liver. Here are some line about Vitamin A

Among them was the sugar, and excessive amounts of fructose, these components are converted by the liver into fat. Recent studies have shown that a fatty liver greatly harm the functioning of the vascular system, thereby greatly reducing life expectancy.

Trans Fats

Trans fats are a man-made fat in some prepackaged foods and baked goods. (You’ll see them listed as “partially hydrogenated” ingredients). A diet high in trans fats makes you a lot of likely to gain weight. That’s not good for your liver. Check the ingredients list. even if it says “0” grams of trans fat, it's going to still have a small amount, and that adds up.

In addition, to interfere with the correct working of the liver can herbal supplements – primarily used in the procedure-appointment. Any supplements ought to be consumed strictly after consulting along with your doctor. the same rule applies to the vitamins, particularly vitamin A.
Are you the one in ten with fatty liver disease?

A poor diet, unhealthy weight, lack of exercise, high cholesterol, diabetes and heart disease can put you in danger of developing non-alcoholic fatty liver disease. affecting 1 in 10 Australians, it’s one of the most common causes of liver problems.

Fat builds up in the liver cells when the liver fails to break down, transfer and store fat effectively, causing abnormal liver perform and inflammation,which can lead to liver scarring (known as cirrhosis).
It is extremely dangerous to the liver TRANS fats – a product resulting from specific processing of vegetable fats. In 2003, the world health organization suggested that TRANS fat content in calorie diet doesn't exceed 1 Chronicles, and in 2009 declared the need to eliminate completely them from the diet. Once in the human body, the molecules of TRANS fats displace the essential fatty acids from cell membranes. It violates the nutrition of cells and doesn't allow them to get rid of waste products. The additional TRANS fats in the diet – the more “dirty” the liver.

Too Much vitamin A From Supplements

Your body needs vitamin A, and it’s fine to get it from plants like fresh fruits and vegetables, especially those that are red, orange, and yellow. however if you're taking supplements that have high doses of vitamin A, that can be a problem for your liver. check with your doctor before you're taking any further vitamin A because you probably don’t want it.

Soda, according to scientists, has on the liver isn't weaker than the alcohol. the combination of large doses of sugar, colors, flavors and other chemical components in these drinks can cause that over time, the lover of soda will develop stenos is – accumulation of fat in liver cells, which ends up in the dysfunction of this vital organ.

Research shows that people who drink a lot of soft drinks are additional likely to have non-alcoholic fatty liver} disease (NAFLD). Studies don’t prove that the drinks were the cause. but if you down a lot of sodas and have been assuming to cut back, this could be a good reason to switch what you sip.